Conserved Rhodopsin Intradiscal Structural Motifs Mediate Stabilization: Effects of Zinc
نویسندگان
چکیده
منابع مشابه
Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors.
G protein-coupled receptors with seven transmembrane alpha-helices (GPCRs) comprise the largest receptor superfamily and are involved in detecting a wide variety of extracellular stimuli. The availability of high-resolution crystal structures of five prototypical GPCRs, bovine and squid rhodopsin, engineered A(2A)-adenosine, beta(1)- and beta(2)-adrenergic receptors, permits comparative analysi...
متن کاملIdentification of multiple distinct Snf2 subfamilies with conserved structural motifs
The Snf2 family of helicase-related proteins includes the catalytic subunits of ATP-dependent chromatin remodelling complexes found in all eukaryotes. These act to regulate the structure and dynamic properties of chromatin and so influence a broad range of nuclear processes. We have exploited progress in genome sequencing to assemble a comprehensive catalogue of over 1300 Snf2 family members. M...
متن کاملConserved structural motifs in cyclins identified by sequence analysis.
Cyclins, as regulatory subunits of the ubiquitous p34cdc2 protein kinase, act as key controlling elements of the eukaryotic cell cycle. We have examined published sequences of A- and B-type cyclins for both amino acid and secondary structure homologies. In particular, we sought regions of homology outside the recognised area of sequence conservation known as the "cyclin box', as well as conserv...
متن کاملZinc-Binding Cysteines: Diverse Functions and Structural Motifs
Cysteine residues are known to perform essential functions within proteins, including binding to various metal ions. In particular, cysteine residues can display high affinity toward zinc ions (Zn2+), and these resulting Zn2+-cysteine complexes are critical mediators of protein structure, catalysis and regulation. Recent advances in both experimental and theoretical platforms have accelerated t...
متن کاملInferring Phylogenetically Conserved Motifs
The regulation of gene expression is a crucial biological process by which genes are turned on or off in the cell. Motifs are short sequence segments which occur in the genome are an important component of this process. Motifs which regulate gene expression are perhaps the second most sought after annotation from a newly sequenced genome after the identification of the protein-coding genes. A v...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemistry
سال: 2009
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi800968w